Laboratory for Brainstem
and Inner Ear Neurobiology
We study how Sensory cells and neurons are specified and differentiate to better understand Nervous system development and pathogenesis of disease.
The Duncan lab utilizes transgenic mice to model biological processes related to human development and disease. Our work focuses on understanding:
The gene regulatory networks necessary for inner ear development and hearing restoration in patients with Age Related Hearing Loss
Prevention of hearing loss
Development of cranial motor neurons and disorders in axonal guidance.
Specification and connectivity of hindbrain neurons involved in sudden infant death syndrome (SIDS).
Jeremy Duncan is an Associate Professor in the Department of Biological Sciences, the Director of the Geriatric Neuroscience Research Group, and an Adjunct Assistant Professor in the Department of Biomedical Science Homer Stryker MD School of Medicine. Jeremy conducts research on neurodevelopmental and inner ear disorders. He has published papers and book chapters on such topics as inner ear & hindbrain development, hearing evolution, cranial nerve disorders, and neuromethodology.
Elizabeth has successfully defended her PhD thesis. Congratulations Dr. Ketchum!
Sydney has successfully defended her PhD thesis. Congratulations
Welcome to the Duncan Lab
Topologically Correct Central Projections of Tetrapod Inner Ear Afferents Require Fzd3
Duncan J.S., Fritzsch B., Houston D.W., Ketchum E.M., Kersigo J., Deans M.R., Elliott K.L., (2019) Scientific Reports, PMCID: PMC6635624
Neuronal Migration Generates New Populations of Neurons that Develop Unique Connections, Physiological Properties and Pathologies
Fritzsch B., Elliott K.L., Pavlinkova G., Duncan J.S., Hansen M.R., Kersigo J.M., (2019) Frontiers in Cell and Developmental Biology, PMCID 31069224
Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding
Stoner, Z.A.*, Ketchum, E.M.* et al, (2022) Frontiers in Neuroscience, PMICD: PMC8828977